A Worldwide Survey of Activities and Practices in Clinical Islet of Langerhans Transplantation

A global online survey was administered to 69 islet transplantation programs, covering 84 centers and 5 networks. The survey addressed questions on program organization and activity in the 2000–2020 period, including impact on activity of national health care coverage policies. We obtained full data from 55 institutions or networks worldwide and basic activity data from 6 centers. Additional data were obtained from alternative sources. A total of 94 institutions and 5 networks was identified as having performed islet allotransplantation. 4,365 islet allotransplants (2,608 in Europe, 1,475 in North America, 135 in Asia, 119 in Oceania, 28 in South America) were reported in 2,170 patients in the survey period. From 15 centers active at the start of the study period, the number of simultaneously active islet centers peaked at 54, to progressively decrease to 26 having performed islet allotransplants in 2020. Notably, only 16 centers/networks have done >100 islet allotransplants in the survey period. Types of transplants performed differed notably between North America and the rest of the world, in particular with respect to the near-absence of simultaneous islet-kidney transplantation. Absence of heath care coverage has significantly hampered transplant activity in the past years and the COVID-19 pandemic in 2020.

If your institution works as part of a network or in bilateral collaborations, please list the names of institutions participating to network or collaboration 10.

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How many ALLOGENEIC islet transplant PROCEDURES have you performed at your institution SINCE 2000 ? * 11.

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In how many different PATIENTS ? * 12.
Enter your answer How many allogeneic islet transplant procedures have you performed in your NETWORK since 2000 ?

13.
Enter your answer In how many different patients ? 14.
Enter your answer How many allogeneic islet transplant procedures have you performed at your institution IN 2020 ? * 15.

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In how many different patients ? * 16.

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How many allogeneic islet transplant procedures have you performed in your network in 2020 ?

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In how many different patients ? 18.

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Which types of islet allo-transplantation procedures do you perform at your institution/network (more than one answer possible) ? * 19. If you selected "Other combinations", please specify 20.

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Which type of islet allo-transplantation procedure is the preferred and most commonly performed at your institution/network (more than one answer possible) ? *

21.
ITA IAK SIK Do you also perform islet auto-transplantation procedures at your institution ? * 22.

Yes No
If you answered yes, how many islet AUTOtransplantation procedures have you performed at your institution SINCE 2000?

23.
Enter your answer If you answered yes to question 22, how many islet AUTOtransplantation procedures have you performed at your institution IN 2020?

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What are the indications for islet auto-transplantation at your institution (more than one answer possible) ? * 25. If you selected "Other", please specify 26.

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What is the preferred and most common indication for islet auto-transplantation at your institution ? * 27. If you answered "other" or "inside device", please specify 33.

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Was you islet transplant program interrupted at any time since 2000 ? * 34.

No
Yes, for allotransplantation only Yes, for allo-and autotransplantation Yes for auto-transplantation only If you answered "yes", is your islet transplantation program still interrupted ? 35.

Yes No
If you entered "yes" to question 29, please indicate the approximate duration and dates of interruption 36.

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If you entered "yes" to question 29, please briefly indicate the reason 37.

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What was the impact of the COVID-19 pandemic on your islet transplantation program (more than one answer possible) ? *

38.
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47.
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